Association of Herpesvirus and Periodontitis: A Clinical and Laboratorial Case-control Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The presence of virus DNA (HSV1, HSV2, EBV and CMV)
研究概览
简要总结
A significant influence of the Herpes viruses family in the progression of periodontal disease has been suggested. The aim of this study was to investigate the potential association of four Herpes viruses (HSV-1, HSV-2, CMV and EBV) with periodontal disease using a qualitative test for evaluating the presence or absence of viral DNA in crevicular fluid samples of both healthy periodontal patients and periodontal compromised patients.
Adult patients with healthy periodontium or periodontally compromised attending the Egas Moniz university dental clinic (Almada, Portugal) are eligible to participate The study involves a periodontal diagnosis and collection of unstimulated crevicular fluid from saliva samples.
There will be no direct benefits for patients, but indirect benefit of advancing science in the study of potential involvment of Herpes viruses in periodontitis. No risks of participating are antecipated as the study material and data will be anonymized.
The study runs from the the Cooperativa de Ensino Egas Moniz and is expected to run for 3 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients (> 18 years of age) with natural teeth attending clinical appointments at the Egas Moniz university dental clinic;
- •Cases (periodontally compromised) included at the Department of Periodontology of the same clinic;
- •Controls (periodontally healthy) included at the remaining departments of the same clinic.
排除标准
- •Occurrence of a viral infection during the six months prior to the clinical study;
- •Exposure to antiviral medication in the six months prior to the survey;
- •Clinical history of immunosuppression, either exogenous or endogenous;
- •Chemotherapy in the previous six months.
结局指标
主要结局
The presence of virus DNA (HSV1, HSV2, EBV and CMV)
时间窗: 1 day
The presence of virus DNA (HSV1, HSV2, EBV and CMV)
次要结局
- Alcohol consumption(one year)
- Smoking(one year)
- Oral hygiene habits(one year)
研究者
Miguel de Araújo Nobre
PhD
Malo Clinic