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Ocular Surface Disease and IOP Monitoring With Travoprost Without Conservatives

Completed
Conditions
Ocular Surface Disease
Glaucoma
Glaucoma; Drugs
Interventions
Diagnostic Test: Intraocular pressure (IOP)
Diagnostic Test: Tear Break-up Time (TBUT)
Diagnostic Test: Conjuctival Hyperemia
Diagnostic Test: Schirmer Test
Diagnostic Test: Visual Fields and OCT RNFL
Registration Number
NCT05319470
Lead Sponsor
Democritus University of Thrace
Brief Summary

Primary objective of this study is to study the efficacy of travoprost without preservatives in the treatment of glaucoma patients and to monitor the ocular surface.

Detailed Description

This is a prospective study including patients visiting the outpatient glaucoma clinic of the University General Hospital of Alexandroupolis for their standard evaluation. Study population is already under treatment with a travoprost preparation without preservatives. They will be fully informed about the procedure and the purpose of the study and a written consent will be obtained. For every patient included in the study intraocular pressure will be measured using a Goldman applanation tonometer, according to the standard way of practice at our clinic. Also, Tear Break-Up-Time (BUT), conjunctival hyperemia grading and Schirmer testing will be used to assess the ocular surface state. Visual field tests and OCT RNFL measurements will also be obtained. The above measurements will be repeated 6 months after the initial examination.

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
25
Inclusion Criteria
  • Patients with glaucoma treated with travoprost without preservatives.
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Exclusion Criteria
  • Co-administration of another anti-glaucoma preparation with or without preservatives, Sjogren's syndrome, poor eyelid occlusion of any etiology.
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Study GroupTear Break-up Time (TBUT)100 patients with diagnosed glaucoma receiving travoprost without preservatives
Study GroupVisual Fields and OCT RNFL100 patients with diagnosed glaucoma receiving travoprost without preservatives
Study GroupIntraocular pressure (IOP)100 patients with diagnosed glaucoma receiving travoprost without preservatives
Study GroupSchirmer Test100 patients with diagnosed glaucoma receiving travoprost without preservatives
Study GroupConjuctival Hyperemia100 patients with diagnosed glaucoma receiving travoprost without preservatives
Primary Outcome Measures
NameTimeMethod
Intraocular Pressure (IOP)6 months

Intraocular pressure measurement in both eyes using the Goldman applanation tonometer.

Ocular Surface Disease6 months

Tear breakup time (TBUT), conjuctival hyperemia scoring and Schirmer testing will be used to assess the ocular surface state of the study population.

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Department of Ophthalmology, University Hospital of Alexandroupolis

🇬🇷

Alexandroupolis, Evros, Greece

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