Biomarkers in Tumor Tissue Samples From Younger Patients With Rhabdomyosarcoma

Completed

• Conditions: Alveolar Childhood Rhabdomyosarcoma; Childhood Rhabdomyosarcoma; Embryonal Childhood Rhabdomyosarcoma
• Interventions: Other: laboratory biomarker analysis

• Registration Number: NCT01496573
• Lead Sponsor: Children's Oncology Group

Brief Summary

This research trial studies biomarkers in tumor tissue samples from younger patients with rhabdomyosarcoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer

Detailed Description

PRIMARY OBJECTIVES:

I. To demonstrate CRKL expression at the protein level in rhabdomyosarcoma tumors by tissue microarray (TMA).

OUTLINE:

Archived tumor tissue samples are analyzed for CRKL expression.

Study Timeline

• Study Start: 2011-12
• Study First Submitted: 2011-12-16
• Study First Submitted QC: 2011-12-17
• Study First Posted: 2011-12-21
• Status Verified: 2016-05
• Primary Completion: 2016-05
• Study Completion: 2016-05
• Last Update Submitted: 2016-05-17
• Last Update Posted: 2016-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 77

Inclusion Criteria

• Alveolar rhabdomyosarcoma and embryonal rhabdomyosarcoma specimens from the Children Oncology Group (COG) tumor microarrays (TMAs)

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Basic science (biomarker analysis)	laboratory biomarker analysis	Archived tumor tissue samples are analyzed for CRKL expression.

Primary Outcome Measures

Name	Time	Method
CRKL expression at the protein level	1 month

Trial Locations

Locations (1)

Children's Oncology Group; 🇺🇸 Monrovia, California, United States