A study on relationship between characteristics of angiotensin II blockade and pleiotropic effects of angiotensin II AT1 receptor antagonists
Phase 4
- Conditions
- hypertension
- Registration Number
- JPRN-UMIN000003502
- Lead Sponsor
- Division of Clinical Pharmacology, Jichi Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who have diabetes, chronic kidney disease, cardiovascular disease, or 3 or more following risk factors: current smoking, inadequately-controlled dyslipidemia, obesity, metabolic syndrome, and early family history of cardiovascular disease. Patients treated with any antihypertensive medication other than Ca channel blocker Patients with moderate or severe liver injury Patients with anemia Patients who are or might become pregnant Patients treated with a medication which is known to affect CYP2C9 activity or glucuronyl transferase activiry
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Associations between the characteristics of angiotensin II blockade and changes in the markers of pleiotropic effects
- Secondary Outcome Measures
Name Time Method pressure-lowering effect pharmacokinetics