Effects of isosorbide mononitrate on cervical ripening

Phase 3

• Conditions: Condition 1: Cervical ripening in pregnancy. Condition 2: Prolonged pregnancy. Condition 3: Failed medical induction of labour.; Maternal care for other abnormalities of cervix; Prolonged pregnancy; Failed medical induction of labor

• Registration Number: IRCT20091023002624N27
• Lead Sponsor: Iran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 September 2018

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 142

Inclusion Criteria

Pregnant
Gestational age of 39 - 41 weeks
Intact membrane
Bishop Score < 6
Singleton
Cephalic presentation
Maternal age between 18- 40 years old

Exclusion Criteria

Anti-hypertensive therapy
Fetal death
Known hypersensitivity to isosorbide mononitrate
Aortic stenosis
Obstructive myocardial hypertrophy
Systolic blood pressure< 95 mm Hg
Cardiovascular collapse

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bishop scores 48 hours after intervention. Timepoint: 48 hours after intervention. Method of measurement: Vaginal examination.

Secondary Outcome Measures

Name	Time	Method
Frequency of vaginal delivery. Timepoint: At birth. Method of measurement: Data sheets.;Gestational age at the onset of spontaneous labor. Timepoint: Onset of spontaneous labor. Method of measurement: Data sheets.;Interval between intervention to delivery. Timepoint: At delivery. Method of measurement: Data sheets.