Sarcopenia and Short Bowel Syndrome: the Microbiota-gut-muscle Axis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Evolution of sarcopenia
研究概览
简要总结
Sarcopenia or the loss of skeletal muscle is highly prevalent in many diseases, including short bowel syndrome (SBS). While adaptation is more likely in SBS patients with a colon-in-continuity, the consequences and underlying mechanisms are unclear. An overabundance of fecal Lactobacillus was found but not yet linked to adaptation or sarcopenia. The objectives are to study the evolution of sarcopenia and the link with intestinal adaptation in SBS.
详细描述
Patients with short bowel syndrome (SBS) will be screened and included in longitudinal or cross-sectional studies if eligible.
The longitudinal study will follow patients with type 1 SBS (enterostomy) before and every 3 months after continuity surgery for 1 year. Cross-sectional studies will follow patients with type 2 or 3 SBS (jejunocolonic or -ileal anastomosis) for 1 year (every 3 months during the first 2 years after continuity surgery or every 6 months after).
Study visits will include clinical examination, nutritional assessment, endoscopy with biopsies and/or intestinal absorption assessment planned as part of routine follow-up. In addition, questionnaires will be completed (GPAQ, SarQoL, EQ-5D -3L, SF36), with collection of stool (for routine and research) and urine samples (for research).
The objective are to study the evolution of sarcopenia and the link with intestinal adaptation in SBS. The results may identify metabolic or microbial biomarkers and predictors of nutritional optimisation in SBS, which is a complex and costly orphan disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years old
- •SBS diagnosis validated by small bowel length and either type 1 (enterostomy), type 2 or 3 (jejuno-colic or -ileal anastomosis)
- •Patient not objecting to the collection of personal data as part of the study
排除标准
- •Pregnancy
- •Remaining hail length unknown
- •Patient expressing opposition to participating in the cohort
- •Patients who are unable to express themselves
结局指标
主要结局
Evolution of sarcopenia
时间窗: at 12 months
Changes in muscle mass (bioimpedance analysis)
次要结局
- Link with intestinal adaptation(at 12 months)
- Quantification of fecal metabolite linked with sarcopenia(at 12 months)
- Quantification of intestinal adsorption and its link with intestinal adaptation(at 12 months)
- Quantification of urinary metabolite linked with sarcopenia(at 12 months)
- Impact of sarcopenia(at 12 months)