NCT06489730尚未招募不适用
HAPH Registry: Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 120
- 主要终点
- Change in pulmonary artery pressure in highlanders
研究概览
简要总结
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study. To this end, the investigators will invite the same highlanders who participate din the study in 2017 to undergo follow-up examinations in 2024, in order to allow comparisons of current results with baseline data from 2017.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Permanently living >2500 m
- •Written informed consent
排除标准
- •Highlanders who cannot follow the study investigations,
- •Patients with moderate to severe concomitant lung disease (FEV1<70% or forced vital capacity <70%), severe parenchymal lung disease, heavy smoking >20 cigarettes/day or >20 pack-years.
- •Coexistent unstable systemic hypertension or coronary artery disease that required adjustment of medication within the last 2 months
- •Regular use of medication that affects control of breathing (benzodiazepines, opioids, acetazolamide)
结局指标
主要结局
Change in pulmonary artery pressure in highlanders
时间窗: Year 2017 to 2024
Change in pulmonary artery pressure (RV/RA measured by echocardiography) from 2017 to 2024 in highlanders living above 2500 m.
次要结局
- Change in pulmonary artery pressure between highlanders and lowlanders(Year 2017 to 2024)
- Progression of quality of life(Year 2017 to 2024)
- Change in TRP/CO in highlanders(Year 2017 to 2024)
- Progression of oxygen desaturation index(Year 2017 to 2024)
- Progression of arterial blood gases(Year 2017 to 2024)
- Progression of right heart strain(Year 2017 to 2024)
研究者
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