NCT03165019已完成不适用
Time Course and Prognostic Significance of Pulmonary Artery Pressure in Highlanders.
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 165
- 试验地点
- 1
- 主要终点
- Changes in pulmonary artery pressure
研究概览
简要总结
The purpose of the current study is to evaluate the clinical and physiologic course of Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a longitudinal cohort study. To this end, the investigators will invite the same highlanders who participated in the study in 2012 to undergo follow-up examinations in 2017, in order to allow comparisons of current results with baseline data from 2012.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure >30 mmHg measured by echocardiography at altitude of residence.
- •healthy subjects (high altitude controls)
- •Both genders
- •Age >16 y
- •Kyrgyz ethnicity
- •born, raised and currently living at >2500 m
- •healthy subjects currently living at <1000 m (low altitude controls)
排除标准
- •Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
- •Excessive erythrocytosis
- •Other coexistent disorders that may interfere with the cardio-respiratory system and sleep
- •Regular use of medication that affects control of breathing
- •Heavy smoking
结局指标
主要结局
Changes in pulmonary artery pressure
时间窗: Year 2012 to 2017
Difference in the change in mean pulmonary artery pressure (mPAP measured by echocardiography) 2012 to 2017 in highlanders with high altitude pulmonary hypertension, healthy highlanders and healthy lowlander
次要结局
- Changes in nocturnal arterial oxygen saturation(Year 2012 to 2017)
- Progression of oxygen desaturation index(Year 2012 to 2017)
- Exercise performance(Year 2012 to 2017)
- Progression of cognitive performance(Year 2012 to 2017)
- Survival(Year 2012 to 2017)
- Progression of quality of life(Year 2012 to 2017)
- Arterial blood gas analysis(Year 2012 to 2017)
研究者
研究点 (1)
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