HCG Versus Spontaneous LH in Intrauterine Insemination (IUI ) Cycles
Early Phase 1
Completed
- Conditions
- Spontaneous Triggering of Ovulation vs. Administration of Human Chorionic Gonadotropin in Patients Undergoing IUI
- Interventions
- Registration Number
- NCT01414673
- Lead Sponsor
- Universitair Ziekenhuis Brussel
- Brief Summary
We recently reported the superiority of the natural cycle to a natural cycle controlled by the administration of human chorionic gonadotropin (hCG) for planning the frozen-thawed embryo transfer cycles, demonstrating a probable negative impact of exogenous hCG on endometrial receptivity.Based on the above findings we conducted the first prospective study that assesses whether there is a difference in pregnancy rate after intrauterine insemination (IUI) in a natural cycle with spontaneous luteinizing hormone (LH) rise compared to natural cycles controlled by hCG for final ovulation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 300
Inclusion Criteria
- age ≤ 36 years,
- regular menstrual cycles,
- body mass index (BMI) between 18 and 29 kg/m²,
- basal levels of FSH (≤ 12 IU/l),
- estradiol (≤ 80 pg/ml) and progesterone (≤ 1.6ng/ml) on day one of the cycle, normal hysterosalpingography (maximum 3 months prior starting the cycle).
- The use of donor sperm was also accepted as inclusion criteria.
Exclusion Criteria
- PCOS
- endometriosis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description spontaneous LH HCG - HCG HCG -
- Primary Outcome Measures
Name Time Method ongoing pregnancy rate 1 year
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Uzbrussel
🇧🇪Brussel, Laarbeeklaan 101, Belgium