Myocellular Signalling in Skeletal Muscle
Not Applicable
Completed
- Conditions
- ExerciseInsulin Sensitivity
- Interventions
- Other: Exercise
- Registration Number
- NCT03203317
- Lead Sponsor
- University of Copenhagen
- Brief Summary
The study will investigate myocellular signalling in skeletal muscle after insulin-stimulation and exercise in healthy young men
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 8
Inclusion Criteria
- healthy
- informed consent
- habitual training (2-5 h/week)
- VO2max of 40-60 ml/min/kg
- lean mass 55-65 kg
Exclusion Criteria
- smoker
- allergy towards insulin
- chronic disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Insulin-stimulation Insulin 2 h insulin-clamp Exercise Exercise 10 min of maximal exercise
- Primary Outcome Measures
Name Time Method Change in muscle phospho-proteome signature Before and after 10 minutes of exercise, as well as before and after a 2 hour insulin stimulation proteomic analysis of mixed muscle homogenate
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie insulin-dependent myocellular signaling in skeletal muscle during exercise in healthy young men?
How does exercise-induced myocellular signaling compare to insulin-stimulated pathways in enhancing skeletal muscle insulin sensitivity?
Are there specific biomarkers that correlate with enhanced myocellular signaling following combined insulin and exercise interventions in skeletal muscle?
What are the potential adverse events associated with combined insulin administration and exercise in healthy young men, and how can they be managed?
What are the related compounds or combination therapies that enhance myocellular signaling in skeletal muscle for improving insulin sensitivity?
Trial Locations
- Locations (1)
August Krogh Building
🇩🇰Copenahgen, Denmark
August Krogh Building🇩🇰Copenahgen, Denmark