NCT03203317已完成不适用
Insulin-dependent and Exercise-induced Myocellular Signalling in Skeletal Muscle
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- Change in muscle phospho-proteome signature
研究概览
简要总结
The study will investigate myocellular signalling in skeletal muscle after insulin-stimulation and exercise in healthy young men
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •informed consent
- •habitual training (2-5 h/week)
- •VO2max of 40-60 ml/min/kg
- •lean mass 55-65 kg
排除标准
- •allergy towards insulin
- •chronic disease
研究组 & 干预措施
Insulin-stimulation
Experimental
2 h insulin-clamp
干预措施: Insulin (Drug)
Exercise
Experimental
10 min of maximal exercise
干预措施: Exercise (Other)
结局指标
主要结局
Change in muscle phospho-proteome signature
时间窗: Before and after 10 minutes of exercise, as well as before and after a 2 hour insulin stimulation
proteomic analysis of mixed muscle homogenate
次要结局
未报告次要终点
研究者
Morten Nielsen
Assistant Professor
University of Copenhagen
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Skeletal Muscle Protein Metabolism and Insulin Sensitivity in Overweight Individuals: Effects of Meals With Various Fatty Acid CompositionsInsulin ResistanceNCT03146286University of Nottingham8
已完成
不适用
Exercise and Insulin Signaling in Human Skeletal MuscleInsulin SensitivitySedentary LifestyleObesityNCT02987491Oregon State University20
已完成
不适用
Molecular Mechanisms of Exercise Benefits to Insulin Resistant PeopleInsulin ResistanceObesityNCT04158375Mayo Clinic58
已完成
不适用
Effect of Exercise on Metabolic HealthObesityNCT02001142University of Michigan15
已完成
不适用
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic SyndromeDiabetes Mellitus, Type 2NCT00690755VA Office of Research and Development157