Skeletal Muscle Protein Metabolism and Insulin Sensitivity in Overweight Individuals: Effects of Meals With Various Fatty Acid Compositions
- Conditions
- Insulin Resistance
- Registration Number
- NCT03146286
- Lead Sponsor
- University of Nottingham
- Brief Summary
The aim of the study will investigate whether impairment in the action of insulin to promote the use of glucose in skeletal muscle (insulin resistance) as a result of oral ingestion of a liquid meal rich in saturated fat is linked to reduced ability of muscles to synthesise new protein in response to dietary protein intake, which ultimately may compromise maintenance of muscle size and quality of life and whether partially replacing saturated fat in the liquid meal with omega 3 polyunsaturated FA (n3PUFA) will ameliorate these negative effects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 8
- Male, healthy, overweight (BMI>27 kg/m2 and fat mass >30%) non-diabetic individuals.
- Diabetes, smoking, cardiovascular disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Change in muscle protein fractional synthetic rate 3 hours post protein drink Measurement of FSR at baseline and post intervention
- Secondary Outcome Measures
Name Time Method whole body postprandial insulin sensitivity Baseline and every 15mins for 7 hours Glucose and insulin area under the curves (AUC) in response to the milk protein and glucose ingestion will be measured
Whole body and skeletal muscle fat oxidation Baseline and every 15mins for 7 hours D31palmitate plasma enrichment and incorporation into skeletal muscle lipids