Skeletal Muscle Protein Metabolism and Insulin Sensitivity in Overweight Individuals: Effects of Meals With Various Fatty Acid Compositions

University of Nottingham0 sites8 target enrollmentAugust 1, 2015

ConditionsInsulin Resistance

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Insulin Resistance
Sponsor: University of Nottingham
Enrollment: 8
Primary Endpoint: Change in muscle protein fractional synthetic rate
Status: Completed
Last Updated: 6 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

The aim of the study will investigate whether impairment in the action of insulin to promote the use of glucose in skeletal muscle (insulin resistance) as a result of oral ingestion of a liquid meal rich in saturated fat is linked to reduced ability of muscles to synthesise new protein in response to dietary protein intake, which ultimately may compromise maintenance of muscle size and quality of life and whether partially replacing saturated fat in the liquid meal with omega 3 polyunsaturated FA (n3PUFA) will ameliorate these negative effects.

Registry

clinicaltrials.gov

Start Date

August 1, 2015

End Date

December 3, 2015

Last Updated

6 years ago

Study Type

Interventional

Study Design

Crossover

Sex

Male

Investigators

Sponsor

University of Nottingham

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Male, healthy, overweight (BMI\>27 kg/m2 and fat mass \>30%) non-diabetic individuals.

Exclusion Criteria

•Diabetes, smoking, cardiovascular disease

Outcomes

Primary Outcomes

Change in muscle protein fractional synthetic rate

Time Frame: 3 hours post protein drink

Measurement of FSR at baseline and post intervention

Secondary Outcomes

whole body postprandial insulin sensitivity(Baseline and every 15mins for 7 hours)
Whole body and skeletal muscle fat oxidation(Baseline and every 15mins for 7 hours)