NLR and Emergency Surgery

Completed

• Conditions: Emergency Surgery

• Registration Number: NCT06549101
• Lead Sponsor: University of Chile

Brief Summary

In the immune system, it has been observed that the preoperative neutrophil-to-lymphocyte ratio (NLR) is an index that reflects the state of inflammation and oxidative stress. In the perioperative period, NLR has been described as a predictor for patients who will develop renal injury, ischemic stroke, and myocardial injury. Since preoperative inflammation is a predictor of morbidity and mortality in patients undergoing non-cardiac surgery, a retrospective analysis of the inflammatory status of patients undergoing surgery at the center is proposed.

Detailed Description

A retrospective analysis of patients operated on at the Clinical Hospital of the University of Chile is proposed. The search will be conducted in the electronic medical records of all patients operated on between January and December 2021, with no exclusion criteria for this analysis. Demographic data, complications, length of hospital stay, and specific characteristics such as the need for mechanical ventilation, time spent in intermediate care units, and ICU as well as total hospitalization time will be recorded. For the purpose of this study, the preoperative complete blood count of the patients will be analyzed to search for hematological variables that reflect the state of preoperative systemic inflammation.

Study Timeline

• Study Start: 2022-09-23
• Primary Completion: 2023-12-30
• Study Completion: 2023-12-30
• Status Verified: 2024-08
• Study First Submitted: 2024-08-07
• Study First Submitted QC: 2024-08-07
• Study First Posted: 2024-08-12
• Last Update Submitted: 2024-12-11
• Last Update Posted: 2024-12-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 851

Inclusion Criteria

• Availability of complete blood count in electronic medical records of all patients operated on between January and December 2021

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
NLR	Day of surgery	Preoperative neutrophil-to-lymphocyte ratio
Mortality	6 months after surgery	30 and 180 days mortality

Trial Locations

Locations (1)

Hospital Clínico de la Universidad de Chile; 🇨🇱 Santiago, Chile