Pathophysiology during neural information processing in ADHD

Recruiting

Conditions: F90
Hyperkinetic disorders

Registration Number: DRKS00014922

Lead Sponsor: Klinik für Psychiatrie und Psychotherapie der Uniklinik Köln

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 32

Inclusion Criteria

Amendment 1+2:
1) Age 18-45
2) Sufficient understanding of the German language for the questionnaire survey
3) Written informed consent of patients
4) Diagnosis of ADHD according to ICD-10
5) Clinically indicated treatment with methylphenidate
6) Stable psychotropic medication (except ADHD medication) for at least 4 weeks

Amendment 1:
unmedicated, concerning methylphenidate

Amendment 2:
Medicated for at least 6 months with methylphenidate

Exclusion Criteria

1. known neurological disorders affecting the brain, including condition after craniocerebral trauma with unconsciousness greater than 5 minutes
2. harmful substance use according to ICD-10
3. taking antipsychotics up to 4 weeks before baseline and during the examination period

For Amendment 1:
4. taking pharmaceuticals for ADHD treatment on the day of the examination (not extended release) or within 48 hours (extended release and atomoxetine) before baseline
For Amendment 2:
4. taking pharmaceuticals for ADHD treatment on the day of the examination (not extemded release) or within 48 hours (extended release and atomoxetine) before baseline, with the exception of methylphenidate

5. motor hyperactivity at the time of measurement that makes an EEG examination impossible
6. known IQ < 70
7. premature birth < 32 wks

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evidence of specific changes in the EEG relative to medication

Secondary Outcome Measures

Name	Time	Method
Relationship between EEG parameters, dosage of medication, neuropsychology and interviews on the current condition (ADHS-E, Wender Utah Rating Scale short form (WURS-K), Wender-Reimherr-Interview (WRI-V), Testbatterie zur Aufmerksamkeitsprüfung (TAP))