Dapagliflozin effects in patients with myocardial infarctio

Phase 3

• Conditions: Myocardial infarction.; ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction

• Registration Number: IRCT20111206008307N44
• Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention
Patients aged between 18 to 80 years
Consented patients

Exclusion Criteria

Pregnancy
Lactation
Renal failure (estimated glomerular filtration rate less than 30 ml/min)
Hepatic failure
Systolic blood pressure less than 100 mmHg
Inflammatory and autoimmune diseases
Diabetes mellitus
Chronic heart failure
Malignancy
Psychiatric disorders
Dapagliflozin contraindications
History of receiving dapagliflozin
History of myocardial infarction
Arrival more than 6 hours from symptoms onset

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ST-segment resolution. Timepoint: Before intervention and 90 min after intervention. Method of measurement: Electrocardiogram.;Cardiac troponin I. Timepoint: before intervention and then every 6 hours for the first 24 hours after intervention and every 12 hours to 72 hours after intervention. Method of measurement: ELISA test.;High-sensitivity C-reactive protein (hs-CRP). Timepoint: Before the intervention and 3 days after the intervention. Method of measurement: Immunoturbidimetry method.;Cardiac ejection fraction. Timepoint: Before the intervention and 40 days after the intervention. Method of measurement: Echocardiography.;Major adverse cardiac events. Timepoint: Within 40 days after Intervention. Method of measurement: Interview.;Quality of life. Timepoint: Before the intervention and 40 days after the intervention. Method of measurement: MacNew questionaire.