Empagliflozin effects in patients with myocardial infarctio

Phase 3

Conditions: Myocardial infarction.
ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction

Registration Number: IRCT20111206008307N42

Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 100

Inclusion Criteria

Patients with STEMI undergoing primary PCI
Patients aged between 18 to 80 years
Consented patients

Exclusion Criteria

Pregnancy
Lactation
Renal failure (eGFR < 30)
Hepatic failure
Systolic blood pressure less than 100 mmHg
Inflammatory and autoimmune diseases
Diabetes mellitus
Chronic heart failure
Cancer
Psychiatric disorders
Empagliflozin contraindications
History of receiving empagliflozin
History of myocardial infarction
Arrival more than 6 hours from symptoms onset

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ST-segment resolution. Timepoint: Before and 90 min after primary percutaneous coronary intervention. Method of measurement: Electrocardiogram.;Cardiac troponin I. Timepoint: At baseline and then every 6 hours for the first 24 hours and every 12 hours to 72 hours after admission. Method of measurement: Laboratory test.;Cardiac ejection fraction. Timepoint: At baseline and 40 days after intervention. Method of measurement: Echocardiography.

Secondary Outcome Measures

Name	Time	Method
High-sensitivity C-reactive protein (hs-CRP). Timepoint: Before primary percutaneous coronary intervention and at discharge. Method of measurement: Laboratory test.;Major adverse cardiac events. Timepoint: Within 40 days after primary percutaneous coronary intervention. Method of measurement: Interview.;Quality of life. Timepoint: At baseline and 40 days after primary percutaneous coronary intervention. Method of measurement: MacNew questionnaire.;TIMI flow. Timepoint: Before and after primary percutaneous coronary intervention. Method of measurement: Angiography.