Ability of Near Infrared Spectroscopy to Isolate Compartments of the Extremity

Completed

• Conditions: Acute Compartment Syndrome
• Interventions: Behavioral: Muscle contraction

• Registration Number: NCT01283451
• Lead Sponsor: J&M Shuler

Brief Summary

Near infrared spectroscopy (NIRS) provides a non-invasive means of continuously monitoring tissue oxygenation, which may be useful for diagnosis of acute compartment syndrome (ACS). Placement of these sensor pads on the surface of the skin must be such that light penetrates the intended compartment without inadvertently obtaining measurements of an adjacent compartment. The objective of this study is to examine whether the NIRS measurements of each compartment truly represent the tissue perfusion of the intended compartment, as indicated by the predictable decrease in muscle oxygenation of a given compartment in response to muscle fatigue. The investigators hypothesize that the tissue oxygenation values of the stimulated compartment will significantly decrease following muscle stimulation, indicating that the intended muscle compartment was successfully isolated. Additionally, the investigators hypothesize that NIRS values of unstimulated muscle compartments will not change from baseline.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Study First Submitted: 2011-01-24
• Study First Submitted QC: 2011-01-25
• Study First Posted: 2011-01-26
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Status Verified: 2018-08
• Last Update Submitted: 2018-08-14
• Last Update Posted: 2018-08-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 63

Inclusion Criteria

• 18-75 years old
• no current extremity injuries
• willing to provide written informed consent

Exclusion Criteria

• history of any anatomy-altering surgery to the extremity in question
• history of peripheral vascular disease
• history of pulmonary disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Exercise	Muscle contraction	NIRS values of all participants will be measured at baseline and following each 30-60 second exercise.

Primary Outcome Measures

Name	Time	Method
Near infrared spectroscopy	<30 minutes	NIRS values will be measured before and after muscle fatigue

Trial Locations

Locations (1)

Athens Orthopedic Clinic, PA; 🇺🇸 Athens, Georgia, United States