Effects of FRAX+SARC-F Pre-screening on Preventing Fragility Fracture and Fall in Community-dwelling Older Adults
- Conditions
- FallAge Related Osteoporosis
- Interventions
- Other: FRAX+SARC-F questionnaire pre-screening
- Registration Number
- NCT04709393
- Lead Sponsor
- Chinese University of Hong Kong
- Brief Summary
Hip fragility fractures are a major threat to functional independence in older adults locally and globally. In Hong Kong, the prevalence of osteoporosis and osteopenia in people aged \>50 years were reported to be as high as 37% and 52%, respectively. The major challenge in fragility fracture prevention is that fragility fracture is caused by the combination of osteoporosis and propensity to fall, and both of these conditions are multifactorial. Ample evidence shows that fall risks can be reduced by well-designed exercises, and osteoporosis can be effectively diagnosed by Dual-energy X-ray Absorptiometry imaging (DXA) and treated with anti-osteoporosis medication. Lifestyle modifications e.g. diet, optimal physical activity, environmental safety can also help to prevent falls or improve bone health. The brief Fracture Risk Assessment Tool (FRAX) and SARC-F provide a low cost of prescreening for fracture risk and sarcopenia, respectively. Using SARC-F in conjunction with FRAX has increased sensitivity for hip fracture risk prediction. FRAX+SARC-F may help increase the public awareness of osteoporosis and get the at-risk group to receive diagnostic tests and be treated. This model should fit in well with the coming District Health Centres across Hong Kong.
- Detailed Description
Participants will be randomly assigned to either the pre-screening or control group in a 1:1 ratio. Independent personnel not involved in data collection or intervention will perform and conceal the randomization using an online data server. Research assistants who are blinded to the group allocation will conduct all the baseline assessments and subsequent event surveillance. All data will also be entered and checked by the blinded research assistants. All procedures concur with the Declaration of Helsinki (2013).
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 2956
- aged ≥ 65 years
- living in the community
• cannot follow the instruction
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Pre-screening FRAX+SARC-F questionnaire pre-screening Receiving FRAX+SARC-F questionnaire pre-screening results on estimated fracture risk
- Primary Outcome Measures
Name Time Method proportions of participants diagnosed with osteoporosis in the FRAX+SARC-F pre-screening and control groups. within 1-6 months proportions of participants diagnosed with osteoporosis in the FRAX+SARC-F pre-screening and control groups.
- Secondary Outcome Measures
Name Time Method Rate of receiving osteoporosis screening 6-12 months Number of participants receiving osteoporosis screening in the arms
rate of receiving fall risk assessment 6-12 months Number of participants receiving fall risk assessment in the arms
rate of receiving fall prevention intervention 6-12 months Number of participants receiving fall prevention intervention in the arms
subsequent fall rate 12 months Number of participants having subsequent fall in the arms
subsequent fracture rate 12 months Number of participants having subsequent fracture in the arms
rate of receiving anti-osteoporosis intervention 6-12 months Number of participants receiving anti-osteoporosis intervention in the arms
Trial Locations
- Locations (1)
The Chinese University of Hong Kong Jockey Club Centre for Osteoporosis Care and Control
🇭🇰Hong Kong, Hong Kong