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临床试验/NCT04292548
NCT04292548已完成不适用

Salivary TAS, TOS, LL-37 and Dental Status in Passive Smoking Children

Merve Erkmen Almaz0 个研究点目标入组 180 人开始时间: 2016年11月16日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
180
主要终点
salivary oxidative stress values: TAS level

研究概览

简要总结

The aim of the present study was to determine the effect of passive smoking on the levels of salivary TAS, TOS, LL-37 and dental status in children.In the study the parents of children were asked to fill out a complete survey about smoking habits. After filling out the questionnaire, according to the survey results, a total of 180 children were included to the study as follows; 90 children exposed to passive smoking, and 90 children in the control group (unexposed controls). Also demographic data were recorded (age, gender, parental education levels, child's tooth-brushing habit and child's daily dietary sugar exposure, family income). Dental examination of children were performed and caries prevalance of the patients were recorded. Unstimulated saliva samples were collected from children. Saliva 'cotinine levels' which are expected to increase in passive smoking group; 'antimicrobial peptide LL-37' and oxidative stress markers 'total antioxidant status' (TAS), and' total oxidant status' (TOS) were evaluated by using Enzyme-linked immunosorbent assay (ELISA). The obtained data parameters of the two groups were evaluated and comparison was performed.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Cross Sectional

入排标准

年龄范围
6 Years 至 12 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Systemically healthy children

排除标准

  • The presence of orthodontic / intraoral appliance
  • Any disease or condition known to affect defense system
  • Uncooperative children

结局指标

主要结局

salivary oxidative stress values: TAS level

时间窗: 1 day (once after the dental examination)

Unstimulated saliva samples were collected from children.

salivary LL-37 level

时间窗: 1 day (once after the dental examination)

Unstimulated saliva samples were collected from children.

salivary oxidative stress values: TOS level

时间窗: 1 day (once after the dental examination)

Unstimulated saliva samples were collected from children.

salivary cotinine levels

时间窗: 1 day (once after the dental examination)

Unstimulated saliva samples were collected from children for describing passive smoking children.

次要结局

未报告次要终点

研究者

发起方
Merve Erkmen Almaz
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Merve Erkmen Almaz

Assist prof

Kırıkkale University

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