Salivary TAS, TOS, LL-37 and Dental Status in Passive Smoking Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 180
- 主要终点
- salivary oxidative stress values: TAS level
研究概览
简要总结
The aim of the present study was to determine the effect of passive smoking on the levels of salivary TAS, TOS, LL-37 and dental status in children.In the study the parents of children were asked to fill out a complete survey about smoking habits. After filling out the questionnaire, according to the survey results, a total of 180 children were included to the study as follows; 90 children exposed to passive smoking, and 90 children in the control group (unexposed controls). Also demographic data were recorded (age, gender, parental education levels, child's tooth-brushing habit and child's daily dietary sugar exposure, family income). Dental examination of children were performed and caries prevalance of the patients were recorded. Unstimulated saliva samples were collected from children. Saliva 'cotinine levels' which are expected to increase in passive smoking group; 'antimicrobial peptide LL-37' and oxidative stress markers 'total antioxidant status' (TAS), and' total oxidant status' (TOS) were evaluated by using Enzyme-linked immunosorbent assay (ELISA). The obtained data parameters of the two groups were evaluated and comparison was performed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 12 Years(Child)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Systemically healthy children
排除标准
- •The presence of orthodontic / intraoral appliance
- •Any disease or condition known to affect defense system
- •Uncooperative children
结局指标
主要结局
salivary oxidative stress values: TAS level
时间窗: 1 day (once after the dental examination)
Unstimulated saliva samples were collected from children.
salivary LL-37 level
时间窗: 1 day (once after the dental examination)
Unstimulated saliva samples were collected from children.
salivary oxidative stress values: TOS level
时间窗: 1 day (once after the dental examination)
Unstimulated saliva samples were collected from children.
salivary cotinine levels
时间窗: 1 day (once after the dental examination)
Unstimulated saliva samples were collected from children for describing passive smoking children.
次要结局
未报告次要终点
研究者
Merve Erkmen Almaz
Assist prof
Kırıkkale University
