Anesthetic preconditioning effects of desflurane versus propofol on tourniquet induced ischemia-reperfusion injury during anterior cruciate ligament reconstruction:a single-centre randomized controlled study.
- Conditions
- Anterior cruciate ligament injury
- Registration Number
- JPRN-UMIN000033217
- Lead Sponsor
- Medical Corporation Sakai Orthopedics Fukuoka Sports Clinic
- Brief Summary
On the contrary to the results obtained in cardiac surgeries, inhalational anesthetic Desflurane showed no advantageous effect over intravenous anesthetic Propofol against ischemia-reperfusion injury during anterior cruciate ligament reconstruction using a tourniquet.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 106
Not provided
1) There has been a history of injury on the same side in the past 2) Cases with complex injuries 3) Patients who are predisposed to allergies to venous anesthetic propofol or volatile anesthetic desflurane 4) Patients contraindicated in regional anesthesia, difficult cases of puncture due to obesity or spinal deformity, patients who have difficulty in prescribing anesthesia and postoperative analgesia due to insufficient anesthetic effect 5) Cases in which a tourniquet pressure was required up to a pressure exceeding 250 mmHg
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Skeletal muscle cell damage quantified by the release of postoperative creatine phosphokinase-MM (CPK-MM) and the areas under the curve of the CPK-MM concentrations over the 24 h (AUC24 h) and the 48h (AUC48 h). Blood samples are taken preoperatively and 6, 12, 24, and 48 h following release of tourniquet.
- Secondary Outcome Measures
Name Time Method Skeletal muscle cell damage quantified by the release of postoperative myoglobin and the areas under the curve of the myoglobin concentrations over the 24 h (AUC24 h) and the 48h (AUC48 h). Blood samples are taken preoperatively and 6, 12, 24, and 48 h following release of tourniquet. For operative side, cross-sectional areas of quadriceps femoralis muscles were traced and calculated on MRI before operation and postoperative day 9th, at two slices of 5 cm and 10 cm above the upper margin of the patella, respectively. Change ratio of the areas at the same slice before and after operation was examined.The change ratios of patinets managed with desflurane were compared with those of patients managed with propofol at the corresponding slice, respectively.