Study of Neutrophils and Circulating Platelets in Correlation With the Activity of T Lymphocytes in Patients With NAFLD (Nonalcoholic Fatty Liver Disease)

• Conditions: NAFLD- Non Alcoholic Fatty Liver Disease

• Registration Number: NCT05358496
• Lead Sponsor: University of L'Aquila

Brief Summary

The aim of the study is to define the relationship between neutrophils, platelets and the activity of T lymphocytes in patients with NAFLD (nonalcoholic fatty liver disease).

This study may predict, in the course of hepatic steatosis, specific phenotypic patterns expressed by PMNs and circulating platelets to evaluate their role in disease progression.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-03
• Study First Submitted: 2021-09-29
• Status Verified: 2022-04
• Study First Submitted QC: 2022-04-27
• Last Update Submitted: 2022-04-27
• Study First Posted: 2022-05-03
• Last Update Posted: 2022-05-03
• Primary Completion: 2022-08-30
• Study Completion: 2022-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patients over 18
• No alcoholic abuse
• Hepatic steatosis diagnosticated by abdominal ultrasound
• Negative hepatitis B and C tests
• No history of hepatic cirrhosis

Exclusion Criteria

• Under 18
• History of alcoholic abuse
• Positive serology for hepatitis B or C
• History of hepatic cirrhosis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
number of Neutrophilis	12 months
Morphology of Circulating Platelets in healthy donors, NAFL, and NASH patients wondering how they may drive and modulate the activity of T cells in this disease	12 months
IL-8(interleukin 8)	12 months
Platelets count in healthy donors, NAFL, and NASH patients	12 months
Morphology of Neutrophilis	12 months

Trial Locations

Locations (1)

Clara Balsano; 🇮🇹 L'Aquila, Italy/L'Aquila, Italy