Study of Neutrophils and Circulating Platelets in Correlation With the Activity of T Lymphocytes in Patients With NAFLD (Nonalcoholic Fatty Liver Disease)
Overview
- Phase
- Not Applicable
- Sponsor
- University of L'Aquila
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- number of Neutrophilis
Overview
Brief Summary
The aim of the study is to define the relationship between neutrophils, platelets and the activity of T lymphocytes in patients with NAFLD (nonalcoholic fatty liver disease).
This study may predict, in the course of hepatic steatosis, specific phenotypic patterns expressed by PMNs and circulating platelets to evaluate their role in disease progression.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patients over 18
- •No alcoholic abuse
- •Hepatic steatosis diagnosticated by abdominal ultrasound
- •Negative hepatitis B and C tests
- •No history of hepatic cirrhosis
Exclusion Criteria
- •History of alcoholic abuse
- •Positive serology for hepatitis B or C
- •History of hepatic cirrhosis
Outcomes
Primary Outcomes
number of Neutrophilis
Time Frame: 12 months
Morphology of Circulating Platelets in healthy donors, NAFL, and NASH patients wondering how they may drive and modulate the activity of T cells in this disease
Time Frame: 12 months
Morphology of Neutrophilis
Time Frame: 12 months
IL-8(interleukin 8)
Time Frame: 12 months
Platelets count in healthy donors, NAFL, and NASH patients
Time Frame: 12 months
Secondary Outcomes
No secondary outcomes reported
Investigators
Clara Balsano
Full Professor
University of L'Aquila