Study of Neutrophils and Circulating Platelets in Correlation With the Activity of T Lymphocytes in Patients With NAFLD (Nonalcoholic Fatty Liver Disease)
- Conditions
- NAFLD- Non Alcoholic Fatty Liver Disease
- Interventions
- Diagnostic Test: Data collection
- Registration Number
- NCT05358496
- Lead Sponsor
- University of L'Aquila
- Brief Summary
The aim of the study is to define the relationship between neutrophils, platelets and the activity of T lymphocytes in patients with NAFLD (nonalcoholic fatty liver disease).
This study may predict, in the course of hepatic steatosis, specific phenotypic patterns expressed by PMNs and circulating platelets to evaluate their role in disease progression.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- Patients over 18
- No alcoholic abuse
- Hepatic steatosis diagnosticated by abdominal ultrasound
- Negative hepatitis B and C tests
- No history of hepatic cirrhosis
Exclusion Criteria
- Under 18
- History of alcoholic abuse
- Positive serology for hepatitis B or C
- History of hepatic cirrhosis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description NAFLD cohort Data collection - Validation cohort Data collection -
- Primary Outcome Measures
Name Time Method Morphology of Neutrophilis 12 months number of Neutrophilis 12 months Morphology of Circulating Platelets in healthy donors, NAFL, and NASH patients wondering how they may drive and modulate the activity of T cells in this disease 12 months IL-8(interleukin 8) 12 months Platelets count in healthy donors, NAFL, and NASH patients 12 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Clara Balsano
🇮🇹L'Aquila, Italy/L'Aquila, Italy