Can heating prevent hyperglycaemia-induced endothelial dysfunction?

Completed

• Conditions: impaired vessel function after a meal; post-prandial endothelial dysfunction; 10012653

• Registration Number: NL-OMON38281
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2014-07-03
• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Diabetes group:
- Older than 40 years
- Diagnosed with type 2 diabetes mellitus at least 2 years ago
Control group:
- Older than 40 years

Exclusion Criteria

Diabetes group:
- Women
- Cardiovascular disease
- Hypercholesterolemia
- Hypertension (>160 mmHg systolic and/or >90 mmHg diastolic pressure) and/or subjects on antihypertensive drugs
- Smoking
- Type I diabetes mellitus
- Older than 70 years
- Subjects with vascular complications due to type 2 diabetes mellitus (e.g. diabetic foot ulcer);Control group:
- Women
- Cardiovascular disease
- Hypercholesterolemia
- Hypertension (>160 mmHg systolic and/or >90 mmHg diastolic pressure) and/or subjects on antihypertensive drugs
- Smoking
- Older than 70 years

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The change in endothelial function after 75-gr glucose (measured as the<br /><br>brachial artery flow-mediated dilation at 3 distinct time-points).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>blood flow (in mL/min)</p><br>