Alterations in Autonomic Cardiovascular Control Induced at Partial G Forces
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- The systolic, diastolic and mean arterial blood pressure (SP, DP, MAP)
研究概览
简要总结
As a direct consequence of exposure to microgravity, astronauts experience a number of physiological changes which can lead to serious medical implications. Most immediate and significant is the headward shift of body fluids and the removal of gravitational loading from bone and muscles, resulting in progressive changes of the cardiovascular and musculoskeletal systems. The cardiovascular systems is subject to rapid changes which has been demonstrated in studies of short term (shuttle) and long term missions to Skylab and MIR.
Our main hypothesis is that there is a linear relationship between the gravity level (0G, 0.16G, 0.38G, 1G, 1.8G) and the cardiovascular parameters (heart rate (HR), heart rate variability (HRV), blood pressure and blood pressure variability (BPV) as well the spectral analysis of HRV and BPV.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy male volunteer
- •aged from 20 to 35
- •affiliated to a Social Security system and, for non-French resident, holding an European Health Insurance Card (EHIC)
- •who accepts to take part in the study
- •who has given their written stated consent
- •who has passed a medical examination similar to a standard aviation medical examination for private pilot aptitude .There will be no additional test
排除标准
- •persons who took part in a previous biomedical research protocol, of which exclusion period is not terminated,
- •persons who take any medication or drugs influencing the autonomic cardiovascular control
研究组 & 干预措施
Cardiovascular parameters measurements
干预措施: Parabolic flight (Other)
Cardiovascular parameters measurements
干预措施: Cardiovascular parameters measurements (Other)
结局指标
主要结局
The systolic, diastolic and mean arterial blood pressure (SP, DP, MAP)
时间窗: baseline
The autonomic cardiovascular control evaluated with a spectral analysis of HRV and BPV.
时间窗: baseline
the blood pressure variability (BPV) derived from the continuous blood pressure recording
时间窗: baseline
The heart rate (HR) and the heart rate variability (HRV) derived from the ECG
时间窗: baseline
次要结局
未报告次要终点