NCT01937286已完成不适用
Single Center Experience Over a Decade in Living Donor Liver Transplantation for Egyptian Patients With Hepatocellular Carcinoma: Stretching the Limits
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 590
- 试验地点
- 1
- 主要终点
- Recurrence of Hepatocellular carcinoma after LDLT
研究概览
简要总结
Within community with high incidence of HCC, stretching the limits could be justified based on tumor characters and its biological behavior
详细描述
590 Egyptian patients underwent LDLT; of them, 172 (32%) patients were transplanted for HCC. Twenty six cases (15.1%) were excluded due to early postoperative mortality (n=22) or due to non HCC related mortality (n=4). One hundred forty six patients were retrospectively reviewed to determine prognostic factors for recurrence.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 62 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Egyptien Patients with HCC
- •Patients within Milan Criteria
- •Patients beyond Milan criteria are selected on a case by case basis until
- •From 2005 , patients beyond Milan criteria are subjected to down staging protocol and then reassessed (pre transplantation local ablative therapy either with RFA or TACE according to the size and the site of the lesion and we wait for 12 weeks after ablation ,only those with well ablated lesions, decreased AFP and no denovo lesions were transplanted).
排除标准
- •• Evidence of macro vascular invasion by CT portography and/or US duplex.
- •Metastatic HCC
- •General contraindications for LT (ongoing sepsis, other major co morbidities,...).
- •Early postoperative mortality (first1 month).
- •Post transplant mortality during the period of follow up due to any cause other than recurrent HCC (e.g. sepsis, rejection, cardiological or cerebrovascular complications...)
结局指标
主要结局
Recurrence of Hepatocellular carcinoma after LDLT
时间窗: at least 6 months
次要结局
未报告次要终点
研究者
Iman Fawzy Montasser
Lecturer of Tropical Medicine
Ain Shams University
研究点 (1)
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