Salvage Living Donor Liver Transplantation for HCC Beyond All Criteria Yield Equivalent Results to Milan Criteria
- Conditions
- Hcc
- Registration Number
- NCT04069416
- Lead Sponsor
- Ain Shams University
- Brief Summary
The present study aims to evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients.
- Detailed Description
Introduction:
HEPATOCELLULAR CARCINOMA (HCC) is the second leading cause of cancer mortality worldwide. Living donor liver transplantation (LDLT) for HCC patients has emerged as a rewarding therapy for a cure and a successful alternative where a Deceased donor liver transplantation (DDLT) program is lacking. Therefore, trials for careful expansion to Milan criteria have been adopted.
Aim of the study:
To evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 241
- All patient transplanted for HCC eligible for transplant (no vascular invasion-no extra hepatic metastasis)
- age>18y
- other etiology for liver transplant rather than HCC
- patient not fit for surgery
- age >70y
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method HCC recurrence 3 years Recurrence of Hepatocellular carcinoma either intra-hepatic, extra-hepatic or both
- Secondary Outcome Measures
Name Time Method