Liver Transplantation for Hepatocellular Carcinoma Arising in Non-cirrhotic Liver: a Propensity Score-matched Retrospective Cohort Study of Two National Databases
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- The overall survival rate was evaluated by follow-up investigation and outpatient review
研究概览
简要总结
Background: Majority of liver transplantation (LT) recipients for hepatocellular carcinoma (HCC) were concomitant with liver cirrhosis, while few researches focusing on recipients without cirrhosis. Here we aim to investigate the prognosis of non-cirrhosis HCC recipients, expecting to provide theoretical basis for further improvement of these patients.
Methods: This retrospective study analyze outcomes between adult HCC recipients arising in non-cirrhotic and cirrhotic liver from two national databases (CLTR and UNOS, January 2015 to December 2020). Based on important variables, 1:2 and 1:1 propensity score matching (PSM) were performed respectively.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •liver transplants, performed from January 2015 to December 2020
排除标准
- •pediatric LT; LT for non-tumor lesions; LT for other malignant tumors (cholangiocarcinoma, carcinoma of gallbladder, mixed carcinoma, and secondary tumors); re-transplantation or combined liver-kidney transplantation; incomplete laboratory or clinical data; death within 1 week due to post-operative hemorrhage after LT.
结局指标
主要结局
The overall survival rate was evaluated by follow-up investigation and outpatient review
时间窗: 1-3 years
Postoperative complications were evaluated by postoperative imaging and serological examination
时间窗: 3 months
Including rejection after liver transplantation, vascular complications, new metabolic diseases and so on
The tumor-free survival rate was evaluated by follow-up investigation and outpatient review
时间窗: 1-3 years
次要结局
未报告次要终点
研究者
Xiao Xu
Principal Investigator, Clinical Professor,PHD,MD
Zhejiang University