Effect of Soluble Triggering Receptor Expressed on Myeloid cells â?? 1 (sTREM-1) and Tumor Necrosis Factor - alpha (TNF-α) in gingival crevicular fluid of health, generalized gingivitis and generalized stage III grade B periodontitis
- Conditions
- Health Condition 1: E119- Type 2 diabetes mellitus without complicationsHealth Condition 2: E119- Type 2 diabetes mellitus without complicationsHealth Condition 3: E119- Type 2 diabetes mellitus without complications
- Registration Number
- CTRI/2023/02/049980
- Lead Sponsor
- ARYA DEVI S
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
a) Individuals with healthy periodontium.
b) Patients with diagnosis of generalized gingivitis.
c) Patients with diagnosis of generalized stage III grade B periodontitis.
(Periodontal health, gingivitis and periodontitis definition will be based on the classification of Gingival and Periodontal Diseases as proposed in 2017 World Workshop)
d) Patients with diagnosis of Type 2 Diabetes Mellitus ( HbA1c < 7 %)
e) Presence of at least 20 natural teeth.
a) Patients with any systemic diseases other than Type 2 Diabetes Mellitus.
b) Subjects who have undergone periodontal therapy in last six months preceding the start of the study.
c) Individuals who have history of any antimicrobial or anti- inflammatory therapy in the last six months.
d) Smokers.
e) Pregnant, lactating and postmenopausal women.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To estimate and correlate the GCF levels of sTREM - 1 and TNF-α in subjects with health, generalized gingivitis and generalized stage III grade B periodontitis. <br/ ><br>Timepoint: At Base Line
- Secondary Outcome Measures
Name Time Method To explore the possibility of using sTREM -1 and TNF- α as a marker of inflammation in generalized stage III grade B periodontitis. <br/ ><br>Timepoint: At baseline