Comparison Between Platelets to Lymphocytes Ratio and Procalcitonin in Prediction of Sepsis Outcome
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The prediction of 28 days mortality.
研究概览
简要总结
The aim of this study is to compare effectiveness of platelets to lymphocytes ratio (PLR) with procalcitonin as a predictor of sepsis outcome.
详细描述
Sepsis is a rapidly progressive, life-threatening disease. Accurate and expeditious assessment of sepsis is important for early administration of antibiotics and removal of the source of infection.
In the 2016 version of the sepsis guidelines (Sepsis-3), the concept of the systemic inflammatory response syndrome has been deleted.
Although most patients with sepsis receive intensive management, such as early goal directed therapy (EGDT), in an emergency department (ED), the mortality rate of sepsis has been reported to be greater than 20% to 30%.
Many clinicians have studied the usefulness of blood biomarkers such as C-reactive protein, procalcitonin, and lactate for early assessment of sepsis and for prognostication, in order to initiate timeous treatment and to prevent rapid progression to multi-organ failure.
Several studies mentioned the advantages of the precursor molecule of calcitonin, namely procalcitonin as a biomarker for sepsis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Septic patients according to Third International Consensus Definitions for Sepsis
- •with ICU stay more than 24 hours will be included.
排除标准
- •Pregnant and women in puerperium.
- •Patients with active hemorrhage
- •Patients with hematological diseases (including bone marrow diseases) and collagen diseases.
- •Patients on corticosteroid therapy or immunosuppressive drugs.
- •Patients who will need immediate surgical interventions.
- •Acute cerebrovascular or coronary syndrome.
- •Patients received blood or platelets transfusion before enrollment in the study.
结局指标
主要结局
The prediction of 28 days mortality.
时间窗: during 28 days from patient admission till patient discharge or death.
Prediction of 28 days mortality in icu patients with sepsis according to change in platlet to lymphocyte ratio
次要结局
- Length of icu stay(throught study comletion, maximum 28 days)
研究者
Mohamed Ahmed Elmalah
assistant lecturer
Tanta University