Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock

• Conditions: Septic Shock

• Registration Number: NCT00378586
• Lead Sponsor: Herlev Hospital

Brief Summary

Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of different inflammatory and infectious markers.

The investigators hypothesize, therefore, that there is a significant difference in the concentrations of inflammatory and infectious markers in the rectal mucosa between patients with septic shock and healthy controls.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2006-09-19
• Study First Submitted QC: 2006-09-19
• Study First Posted: 2006-09-20
• Status Verified: 2009-06
• Last Update Submitted: 2009-06-22
• Last Update Posted: 2009-06-23
• Study Start: 2010-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Septic shock

Exclusion Criteria

• Age < 18 years
• No next of kin
• Pathology of the descending or sigmoid colon or rectum
• Pregnancy
• 1st degree relatives with inflammatory bowel disease
• Severe coagulopathy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Dept. of Intensive Care 4131; 🇩🇰 Copenhagen, Denmark