Barrier Function and Production of Inflammatory Cytokines in the Rectal Mucosa in Patients With Septic Shock
- Conditions
- Septic Shock
- Registration Number
- NCT00378586
- Lead Sponsor
- Herlev Hospital
- Brief Summary
Life-threatening infection impairs bloodflow to the gut, thereby causing less delivery of oxygen. This leads to increased formation of different inflammatory and infectious markers.
The investigators hypothesize, therefore, that there is a significant difference in the concentrations of inflammatory and infectious markers in the rectal mucosa between patients with septic shock and healthy controls.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Septic shock
Exclusion Criteria
- Age < 18 years
- No next of kin
- Pathology of the descending or sigmoid colon or rectum
- Pregnancy
- 1st degree relatives with inflammatory bowel disease
- Severe coagulopathy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular pathways in rectal mucosa are linked to septic shock-induced gut barrier dysfunction in NCT00378586?
How do rectal mucosa cytokine levels compare to other gut biomarkers in predicting septic shock outcomes?
Which rectal mucosa biomarkers predict severity or response to treatment in septic shock patients per NCT00378586 findings?
What adverse events correlate with rectal mucosa inflammatory markers in septic shock patients from NCT00378586?
Are tight junction modulators or anti-inflammatory agents effective in septic shock with gut barrier impairment as per NCT00378586 data?
Trial Locations
- Locations (1)
Dept. of Intensive Care 4131
🇩🇰Copenhagen, Denmark
Dept. of Intensive Care 4131🇩🇰Copenhagen, DenmarkMichael Ibsen, MDContact+45 45 35 94 18micibs@dadlnet.dk