DPP3 levels in out of hospital cardiac arrest patients admitted to the intensive care unit: an explorative study
Completed
- Conditions
- 'cardiac arrest''heart-attack''out of hospital cardiac arrest'1001928010011954
- Registration Number
- NL-OMON50128
- Lead Sponsor
- Radboud Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
- Out of hospital cardiac arrest
- Intensive Care admission (this applies to all out-of-hospital cardiac arrest
patients who required endotracheal intubation because they did not regain
consciousness within 20 minutes of onset of cardiac arrest)
Exclusion Criteria
- Necessity for extracorporeal membrane oxygenation, intra-aortic balloon pumps
- Patients admitted with an already proposed withdrawal of life-sustaining
treatment because of diagnosed irreversible neurological injury or because of
treatment limitations expressed by the patient before the event.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Plasma DPP3 levels and DPP3 enzyme activity. Correlation with development of<br /><br>post-cardiac arrest syndrome, 28 day mortality.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Development of vasodilatory shock with concurrent vasopressor dosage necessity,<br /><br>plasma cytokine concentrations, development of other complications related to<br /><br>disease/treatment, vital parameters, kidney function, blood gas values, age,<br /><br>body mass index, cause of cardiac arrest, sequential organ failure assessment<br /><br>(SOFA) score, use of medication, survival</p><br>