Efficacy of antiviral medications in controlling vertigo attacks of patients with Meniere's Disease
Phase 2
- Conditions
- Meniere's disease.Labyrinthine hydrops Ménière's syndrome or vertigo
- Registration Number
- IRCT138901023597N1
- Lead Sponsor
- Vice Chancellor of Research, Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
1. Patients' willingness to participate in the study 2. Willingness to participate in follow ups 3. Age of 18 or older 4. Having at least 2 vertigos per month each lasting for at least 20 minutes, severely interfering with function 5. Not on medication for at least 3 months before starting the trial.
Exclusion Criteria
1. History of Allergy to Acyclovir or the drugs in the same category 2. Renal insufficiency or having Creatinine more than 1.5 mg/dl 3. Hepatic enzymes more than 3 times normal 4. Hematocrit less than 30% 5. Thrombocytopenia 6. Having a serious uncontrolled illness 7. Pregnant or nursing ladies 8. Using Probenecid 9. Previous surgeries on endolymphatic sac.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Vertigo. Timepoint: Before intervention, 1 month, 3 months and 6 months after the intervention. Method of measurement: Subjective.
- Secondary Outcome Measures
Name Time Method Aural fullness. Timepoint: Before intervention, 1 month, 3 months and 6 months after the intervention. Method of measurement: Subjective evaluation in a 0(with no symptom) to 4 (very severe) scale.;Incidence of patients experiencing nausea as side effect. Timepoint: Before intervention, 1 month, 3 months and 6 months after the intervention. Method of measurement: Patient's subjective evaluation.;Tinnitus. Timepoint: Before intervention, 1 month, 3 months and 6 months after the intervention. Method of measurement: Subjective evaluation in a 0 (with no symptom) to 4 (very severe) scale.;Change in renal function as a side effect. Timepoint: Before intervention, 1 month, 3 months and 6 months after the intervention. Method of measurement: Renal function test , if history suggestive of that.;Hearing. Timepoint: Before intervention, 1 month, 3 months and 6 months after the intervention. Method of measurement: Audiometry and also subjective evaluation.