NCT00902057
Unknown
Phase 4
Effect of Desmopressin on Platelet Dysfunction Associated With Mild Hypothermia in Healthy Volunteers
Overview
- Phase
- Phase 4
- Sponsor
- The University of Hong Kong
- Enrollment
- 48
- Locations
- 1
- Primary Endpoint
- closure time on PFA-100
Overview
Brief Summary
To study, with a prospective randomised controlled design, whether the subcutaneous administration of the haemostatic drug desmopressin, may improve the impairment of primary haemostasis due to mildly decreased temperature.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy volunteers
Exclusion Criteria
- •Any known platelet or coagulation disorder.
- •Pregnant or lactating women.
- •Known chronic liver or renal disease.
- •Coronary artery, carotid artery or peripheral artery disease
- •Recent history of taking antiplatelet drugs, anticoagulants or herbal preparations.
- •Smoker or alcohol user
- •Mentally incapable of providing informed consent
- •Students or junior staff members who had direct working relationship with the PI
Arms & Interventions
desmopressin 1.5
Active Comparator
Intervention: desmopressin (Drug)
desmopressin 3
Active Comparator
Intervention: desmopressin (Drug)
desmopressin 15
Active Comparator
Intervention: desmopressin (Drug)
placebo
Placebo Comparator
Intervention: placebo (Drug)
Outcomes
Primary Outcomes
closure time on PFA-100
Time Frame: 3 hours
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
Loading locations...
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