NCT00902057Unknown4 期
Effect of Desmopressin on Platelet Dysfunction Associated With Mild Hypothermia in Healthy Volunteers
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 入组人数
- 48
- 试验地点
- 1
- 主要终点
- closure time on PFA-100
研究概览
简要总结
To study, with a prospective randomised controlled design, whether the subcutaneous administration of the haemostatic drug desmopressin, may improve the impairment of primary haemostasis due to mildly decreased temperature.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy volunteers
排除标准
- •Any known platelet or coagulation disorder.
- •Pregnant or lactating women.
- •Known chronic liver or renal disease.
- •Coronary artery, carotid artery or peripheral artery disease
- •Recent history of taking antiplatelet drugs, anticoagulants or herbal preparations.
- •Smoker or alcohol user
- •Mentally incapable of providing informed consent
- •Students or junior staff members who had direct working relationship with the PI
研究组 & 干预措施
desmopressin 1.5
Active Comparator
干预措施: desmopressin (Drug)
desmopressin 3
Active Comparator
干预措施: desmopressin (Drug)
desmopressin 15
Active Comparator
干预措施: desmopressin (Drug)
placebo
Placebo Comparator
干预措施: placebo (Drug)
结局指标
主要结局
closure time on PFA-100
时间窗: 3 hours
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
Unknown
4 期
Effects of Prophylactic Desmopressin on Blood Coagulation Parameters in Heart Valve SurgeryBlood Coagulation DisordersC.Surgical Procedure CardiacNCT03343418Instituto do Coracao108
已完成
不适用
Effect of Aspirin, Hemodilution and Desmopressin on Platelet DysfunctionPlatelet DysfunctionHemodilutionMild HypothermiaNSAIDDesmopressinNCT01382134The University of Hong Kong60
已完成
3 期
Desmopressin Response in the YoungPrimary Nocturnal EnuresisNCT00230594Ferring Pharmaceuticals132
已完成
1 期
Effect of Desmopressin on Platelet Function in CKD Patients on Antiplatelet DrugBleedingTachycardiaDyspneaNCT01841515University of Ulsan25
已完成
2 期
Desmopressin for treatment of stroke patients on antiplatelet therapyHaemorrhagic strokeCirculatory SystemIntracerebral haemorrhageISRCTN67038373niversity of Nottingham54