Desmopressin for Bleeding Related to Low Body Temperature

Phase 4

• Conditions: Hypothermia Induced Impairment of Primary Haemostasis
• Interventions: Drug: placebo; Drug: desmopressin

• Registration Number: NCT00902057
• Lead Sponsor: The University of Hong Kong

Brief Summary

To study, with a prospective randomised controlled design, whether the subcutaneous administration of the haemostatic drug desmopressin, may improve the impairment of primary haemostasis due to mildly decreased temperature.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-05
• Study First Submitted: 2009-05-13
• Study First Submitted QC: 2009-05-13
• Last Update Submitted: 2009-05-13
• Study First Posted: 2009-05-14
• Last Update Posted: 2009-05-14
• Study Start: 2009-06
• Primary Completion: 2010-12
• Study Completion: 2011-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

1. Healthy volunteers

Exclusion Criteria

1. Any known platelet or coagulation disorder.
2. Pregnant or lactating women.
3. Known chronic liver or renal disease.
4. Coronary artery, carotid artery or peripheral artery disease
5. Recent history of taking antiplatelet drugs, anticoagulants or herbal preparations.
6. Smoker or alcohol user
7. Mentally incapable of providing informed consent
8. Students or junior staff members who had direct working relationship with the PI

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
placebo	placebo	-
desmopressin 1.5	desmopressin	-
desmopressin 15	desmopressin	-
desmopressin 3	desmopressin	-

Primary Outcome Measures

Name	Time	Method
closure time on PFA-100	3 hours

Trial Locations

Locations (1)

The University of Hong Kong; 🇨🇳 Hong Kong, Hong Kong, China