Achalasia and Dysplasia
- Conditions
- Relation Between Food Stasis and DysplasiaDysplasia in Longstanding Achalasia
- Interventions
- Other: chromoendoscopy
- Registration Number
- NCT02010983
- Lead Sponsor
- KU Leuven
- Brief Summary
Patient with achalasia have a 10-50 fold increased risk to develop esophageal squamous cell carcinoma (ESCC). Early diagnosis of ESCC is essential, and detection of an earlier dysplastic stage is preferred. Endoscopic detection is however difficult and often delayed. Chromoendoscopy with Lugol dye increases detection rates dysplasia and ESCC to 91-100%. The aim of this study was therefore to evaluate a screening program using chromoendoscopy with Lugol to detect dysplasia in patients with idiopathic achalasia.
A second objective is to study the relationship between foodstasis and the development op dysplasia
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 80
- longstanding achalasia (> 15y)
- > 18y old
- informed consent
- allergy to iodine
- esophageal carcinoma
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description longstanding achalasia chromoendoscopy -
- Primary Outcome Measures
Name Time Method incidence of dysplasia in patients with longstanding achalasia 1 year
- Secondary Outcome Measures
Name Time Method additive value of chromoendoscopy in comparison with lugol stain 1 year relationship between food stasis and dysplasia 1 year * relationship between elevated LES pressure and dysplasia
* relationship between stasis on EndoFLIP and dysplasia
* relationship between stasis on timed barium esophagogram and dysplasia
Trial Locations
- Locations (1)
UZleuven
🇧🇪Leuven, Belgium