Endoscopic screening for dysplasia in patients with longstanding ulcerative colitis: Classical chromo-endoscopy versus NBI, FICE and I-sca
Recruiting
- Conditions
- dysplasia1001799010017998ulcerative colitis10017991
- Registration Number
- NL-OMON38174
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 164
Inclusion Criteria
Signed informed consent form
Patients with longstanding ulcerative colitis: at least 8 years after diagnosis or pancolitis and 10 years after diagnosis of left-sided colitis
Sex: both males and females
Age: above 18 years
Exclusion Criteria
Active ulcerative colitis
Personal history of colorectal cancer
Allergy or intolerance to methylene blue
Refusing or incapable to agree with informed consent
Pregnant women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter will be the difference between the three different<br /><br>techniques in the detection of neoplastic lesions in patients with longstanding<br /><br>ulcerative colitis. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Other end-points are: number of biopsies taken in the different groups, number<br /><br>of detected neoplastic lesions for each technique, number of detected<br /><br>non-neoplastic lesions for each technique, the total number of advanced adenoma<br /><br>defined as adenoma with high grade dysplasia, villous components, intramucosal<br /><br>carcinoma and angio-invasive growth, proportion of patients with low grade<br /><br>adenoma, proportion of patients with high grade adenoma and the duration of<br /><br>total endoscopic procedure time and of endoscopic procedure time during<br /><br>retraction for each technique.</p><br>