*Diagnostic role of upper endoscopy in differentiating ulcerative colitis from Crohn*s disease in adults*

Recruiting

• Conditions: Crohn's disease; inflammatory bowel disease; 10017969

• Registration Number: NL-OMON33405
• Lead Sponsor: Rijnstate Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 233

Inclusion Criteria

Patients clinically suspected of IBD (chronic diarrhoea, abdominal pain) and endoscopic lesions suggestive for IBD.
All patients must be >18 years old and give informed consent.

Exclusion Criteria

Patients with a history of stomach resection, Helicobacter pylori treatment in the last six months, and patients in whom discontinuation of NSAID*s or proton pomp inhibitor (PPI*s) is absolutely contraindicated.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. The difference between the prevalence of 'focal enhanced gastritis'in<br /><br>gastric biopsies of patients with Crohn*s disease (CD) and ulcerative colitis<br /><br>(UC).<br /><br>2. The difference in the T-cel subpopulations and their proinflammatory<br /><br>cytokine profile in blood and the inflamed gastric and intestinal mucosa<br /><br>between patients with different IBD phenotyes (CD, UC and IBD unclassified).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Description of specific histological lesions, other than focal enhanced<br /><br>gastritis in gastric mucosa of patients with different IBD phenotype.</p><br>