Young Smokers Have Impaired Airway Defense
- Conditions
- Smoking
- Registration Number
- NCT01877291
- Lead Sponsor
- University of Sao Paulo
- Brief Summary
Background: Smoking is a key factor for development and progression of chronic obstructive pulmonary disease (COPD). Although persons with COPD often have concomitant nasal disease, there are few studies that report physiological or inflammatory changes in the upper airways in young asymptomatic smokers. The investigators investigated physiologic and inflammatory changes in the nasal and lower airways of young smokers and if these changes were related to smoking history.
Methods: Seventy-two subjects aged ≤ 35 years (32 healthy nonsmokers and 40 young smokers) participated in this study. The investigators measured nasal mucociliary clearance (MCC), nasal mucus physical properties, cell count, myeloperoxidase and cytokines concentrations in nasal lavage fluid, exhaled breath condensate (EBC) pH and lung function.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 72
- healthy nonsmokers
- asymptomatic smokers
- after obtaining written informed consent
- inability to understand and follow commands
- previous nasal surgery
- respiratory infection in the previous 30 days
- reported or diagnosed asthma
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Exhaled Breath Condensate pH six months
- Secondary Outcome Measures
Name Time Method mucociliary clearance by saccharine transit time test six months
Trial Locations
- Locations (1)
Faculdade de Medicina da Universidade de São Paulo
🇧🇷São Paulo, SP, Brazil