Pathophysiologic Changes in the Respiratory System After Fire Smoke Inhalation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Bronchial Asthma
- Sponsor
- Oslo University Hospital
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Positive metacholine test (bronchial hyperreactivity).
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Fire smoke inhalation may contribute to intrabronchial inflammation, airway obstruction and impaired gas exchange. In this study the investigators will examine if the scope of inhalation injury can be assessed soon after hospital admission based on clinical markers, biochemical markers, Peak Expiratory Flow (PEF), spirometry and bronchoscopy. At 6 months a lung function test and metacholine test will be performed to examine whether patients have developed increased bronchial hyperreactivity (asthma) or not after the initial fire smoke exposure.
Detailed Description
Fire smoke inhalation may contribute to intrabronchial inflammation, airway obstruction and impaired gas exchange. The scope of injury in fire smoke victims ranges from cough and minor airway irritation to severe respiratory failure and long term mechanical ventilation in the Intensive Care Unit. Some patients with high HbCO-levels are also treated with hyperbaric oxygen therapy. In this study the investigators will examine if the scope of inhalation injury can be assessed soon after admission based on clinical markers, biochemical markers, Peak Expiratory Flow (PEF), spirometry and bronchoscopy. The clinical effect of fiberoptic bronchoscopy after severe smoke inhalation will also be examined. At 6 months a lung function test and metacholine test will be performed to examine whether they have developed asthma/increased bronchial hyperreactivity or not after the initial fire smoke exposure. Lab staff (flowcytometer and cytokine analysis) are unaware of patient identity and whether the patient is a smoke-exposed patient or a healthy volunteer in the control group of non-exposed persons.
Investigators
Espen Rostrup Nakstad
MD
Oslo University Hospital
Eligibility Criteria
Inclusion Criteria
- •fire smoke exposed patient
- •\> 18 years of age
- •admitted to hospital
Exclusion Criteria
- •\< 18 years of ager
- •trauma patient
- •Control group (healthy volunteers/hospital staff):
- •\> 18 years of age
- •non-smoker
- •no exposure to fire smoke
Outcomes
Primary Outcomes
Positive metacholine test (bronchial hyperreactivity).
Time Frame: 6 months
At 6 months a lung function test and metacholine test will be performed to examine whether patients have developed asthma/increased bronchial hyperreactivity after the initial fire smoke exposure.