Effects of smoking and oxidative stress on airway remodeling and phenotypic changes of the airway epithelium in asthma and COPD: strategies to restore the epithelial barrier, repair and steroid sensitivity - Effects of oxidative stress on epithelial cells and steroid-sensitivity

niversitair Medisch Centrum Groningen0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年5月6日

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•inclusion criteria for patients with allergic asthma : ;* Age between 18 and 65 years.
•* * 10 packyears, no smoking in the last year.
•* The presence of allergy defined as at least one positive wheal/flare reaction (*2 mm relative to control) to a skin prick test with sixteen common aero-allergens).
•* FEV1 > 80% predicted.
•* PC20 methacholine or PC20 histamine < 8 mg/ml.;inclusion criteria for patients with COPD :
•* Age between 45-75 years.
•* * 10 packyears.
•* FEV1 between 30% and 80% of predicted.

•*Any disease that, as judged by the Investigator, could have affected the outcome of this study.
•*A respiratory tract infection within 4 weeks of the start of the study.
•*A history of life-threatening asthma, defined as exacerbation of asthma or COPD that required intubation or was associated with hypercapnea.
•*History of myocardial infarction or documented myocardial ischemia.
•*Pregnancy, or the possibility of being pregnant (a pregnancy test will be performed in women of childbearing potential who do not use adequate anticonception as judged by the investigator).

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