Shifting pain modulation towards anti-nociceptivity: Mechanism-specific pharmacological prevention of post sternotomy pai

Completed

• Conditions: chronic pain; post surgical pain; 10034606

• Registration Number: NL-OMON44134
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Trial ended prematurely

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-09-12
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 75

Inclusion Criteria

Patients of either sex with American Society of Anesthesiologists score 1, 2 or 3, aged 18 to 75 years planned to undergo elective surgery involving a sternotomy may be enrolled in the study.

Exclusion Criteria

1. Pain scores > 3 (on a 11-point numerical rating scale, NRS) reported for most of the day during the past month (including angina);
2. The presence of any chronic pain disorder;
3. Regular use of analgesics for any purpose, including SNRIs, gabapentinoids, COX inhibitors or NSAIDs during the previous month;
4. Use of MAO-inhibitors within the last 14 days;
5. The presence of narrow-angle glaucoma;
6. Inability to perform psychophysical testing (eg. in case of cognitive or psychiatric disorders);
7. Patients suffering from cognitive dysfunction;
8. Patients being treated for depression, or any other mood disorder;
9. Inability to give informed consent;
10. Inability to communicate with the investigators;
11. Known allergies to the study medication:
12. Uncontrolled hypertension (diastolic blood pressure > 100 mmHg).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Chronic pain 3 months after surgery</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Acute postoperative pain<br /><br>2. Chronic pain 1 year after surgery</p><br>