the MASTER study
- Conditions
- Coronary bypass, chronic pain, duloxetine, pregabalin, placebo
- Registration Number
- NL-OMON22036
- Lead Sponsor
- eiden University Medical Center (LUMC)
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 500
Inclusion Criteria
Patients of either sex with American Society of Anesthesiologists score 1, 2 or 3, aged 18 to 70 years planned to undergo elective surgery involving a sternotomy may be enrolled in the study.
Exclusion Criteria
1. Pain scores > 3 (on a 11-point numerical rating scale, NRS) reported for most of the day during the past month (including angina);
2. The presence of any chronic pain disorder;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Pain on visual analogue scale (VAS)<br /><br>- Conditioned pain modulation (CPM)<br /><br>- STAI (State-Trait Anxiety Inventory)<br /><br>- PCS (Pain Catastrophizing Scale)<br /><br>- The Big Five Inventory (BFI)<br /><br>- Hospital Anxiety and Depression Score (HADS)
- Secondary Outcome Measures
Name Time Method Chronic pain development