HIIT Improves Survival of Heart Failure Patients
- Conditions
- Heart FailureCardiac RehabilitationCardiac Remodeling, Ventricular
- Interventions
- Behavioral: High-intensity interval training
- Registration Number
- NCT03245125
- Lead Sponsor
- Chang Gung Memorial Hospital
- Brief Summary
BACKGROUND Global burdens of heart failure (HF) are increasing in modern societies. High-intensity interval training (HIIT) increases peak oxygen consumption (VO2peak) in HF patients, which was hypothesized to improve the survival of HF patients.
OBJECTIVES The cohort study aimed to highlight the effect of HIIT on long-term survivals of HF patients.
METHODS 329 HF patients, enrolled between 2009 and 2016, received multidisciplinary disease management program (MDP). They had cardiopulmonary exercise test for peak exercise capacity (VO2peak), echocardiographic examination for left ventricular ejection fraction (LVEF), LV end-diastolic diameter (LVEDD), and LV end-systolic diameter (LVESD), b-type natriuretic peptide (BNP), and quality of life questionnaire. HF patients with LVEF≤ 40% (HFrEF) and HF patients with LVEF\> 40% (HFpEF) underwent≥ 36 times of HIIT. HFrEF and HFpEF patients were classified as the MDP group. Generalized estimating equation (GEE) was used to estimate the interaction between time and VO2peak, LVEF, LVEDD, LVESD, and BNP during the follow-up. Survival analysis was conducted to assess effects of HIIT on the long-term survival of HF during at end of the study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 329
From January 1st, 2009 to December 31st, 2016, HF patients, defined according to the European society of cardiology, with stable clinical status greater than 4 weeks after optimal treatment were enrolled in the study.
Those, who were ≥ 80 years and < 20 years, unable to perform exercise caused by other non-cardiac disease, pregnant, future cardiac transplantation within 6 months, uncompensated HF patients, pacemaker patients, and renal patients with estimated glomerular filtration rate < 30 ml/min/1.73m2, were not candidates in the study. Patients had absolute contraindications for cardiopulmonary exercise test (CPET) and aerobic activities, suggested by the American College of Sports Medicine (ACSM), were also excluded in the study.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description HIIT subjects in HFpEF patients High-intensity interval training heart failure patients with preserved ejection fraction (HFpEF) received at least 36 times of high-intensity interval training (HIIT) MDP subjects in HFrEF patients High-intensity interval training heart failure patients with reduced ejection fraction (HFrEF) received only multidisciplinary disease management program (MDP) and underwent less than 36 times of high-intensity interval training (HIIT) or no exercise training HIIT subjects in HFrEF patients High-intensity interval training heart failure patients with reduced ejection fraction (HFrEF) received at least 36 times of high-intensity interval training (HIIT) MDP subjects in HFpEF patients High-intensity interval training heart failure patients with preserved ejection fraction (HFpEF) received only multidisciplinary disease management program (MDP) and underwent less than 36 times of high-intensity interval training (HIIT) or no exercise training
- Primary Outcome Measures
Name Time Method all-cause death 2009/1/1 to 2016/12/31 Any mortality during the study period
all-cause re-admission 2009/1/1 to 2016/12/31 Any re-admission during the study period
- Secondary Outcome Measures
Name Time Method