Cardiovascular Effects of High-Intensity Interval Training (HIIT)
- Conditions
- Healthy Sedentary Adults With BP <140/90
- Interventions
- Behavioral: High-Intensity Interval TrainingBehavioral: Moderate-Intensity Continuous Training
- Registration Number
- NCT03602170
- Lead Sponsor
- University of Delaware
- Brief Summary
The purpose of this study is to determine the effect of high-intensity interval training (HIIT) in comparison to moderate-intensity continuous training (MCT) on blood pressure, blood vessel function, and blood pressure reactivity.
- Detailed Description
It is estimated that one-third of the adult population in the United States has blood pressure values that are classified as prehypertension. This slight elevation in blood pressure has been shown to result in an increased risk for developing hypertension and cardiovascular disease. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC7) recommends lifestyle modifications for individuals classified as prehypertensive. One lifestyle modification suggested by JNC7 is regular physical activity. Aerobic exercise, like moderate-intensity continuous training (MCT), has been shown to improve blood pressure, blood vessel function, and arterial stiffness in those with prehypertension. However, a major barrier to exercise adherence is the time commitment required. High-Intensity Interval Training (HIIT), which requires individuals to work at higher intensities for shorter durations, may offer an alternative training design that would reduce the time commitment. Previous studies have shown HIIT to be equal to or better at improving cardiorespiratory fitness and blood vessel function in multiple populations. Limited information is present on HIIT training in those with prehypertension. In this study, participants will be randomized into one of the two training program designs mentioned above (MCT or HIIT). Both programs will be completed over an 8-week period (3 sessions per week) and each training session will be supervised. Participants will complete testing visits before and after the training program to collect measures of cardiovascular health (exercise capacity, blood pressure, blood vessel function, and blood pressure reactivity). The goal is to compare the effects of the training programs on these measures of cardiovascular health.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- Blood Pressure less than 140/90 mmHg
- Sedentary
- Known or major signs/symptoms of cardiovascular, pulmonary, renal, or metabolic disease
- Cancer
- Use of antihypertensive medication
- Current tobacco use
- BMI (body mass index) less than 30 kg/m2
- Postmenopausal
- Current pregnancy
- Current hormone replacement therapy
- Participating in regular aerobic exercise at least three times a week for 30 minutes at a moderate intensity for the past 3 months or more
- Not able to regularly exercise for any reason
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description High-Intensity Interval Training High-Intensity Interval Training 8 weeks of high-intensity interval training. Three sessions per week will be performed (24 total sessions). Moderate-Intensity Continuous Training Moderate-Intensity Continuous Training 8 weeks of moderate-intensity continuous training. Three sessions per week will be performed (24 total sessions).
- Primary Outcome Measures
Name Time Method Blood Pressure Change from baseline resting blood pressure at 8 weeks Resting blood pressures measuring by automated oscillometric device
- Secondary Outcome Measures
Name Time Method Pulse Wave Analysis Change from baseline central blood pressure measures at 8 weeks Central blood pressure measures assessed by radial tonometry
Arterial stiffness Change from baseline pulse wave velocity measures at 8 weeks Pulse wave velocity measures (carotid to femoral and femoral to distal) assessed by applanation tonometry
Peak Aerobic Capacity Change from baseline VO2peak at 8 weeks Peak oxygen uptake (VO2peak/max) during incremental cycling exercise until exhaustion
24-Hour Ambulatory Blood Pressure Change from baseline 24-hour ambulatory blood pressure at 8 weeks 24 hours of continuous ambulatory blood pressure monitoring by oscillometric device
Endothelial Function Change from baseline endothelial function at 8 weeks Assessed by brachial artery flow mediated dilation and change in blood in femoral artery in response to passive limb movement
Blood Pressure Reactivity Change from baseline blood pressure reactivity at 8 weeks Blood pressure response to graded exercise test and handgrip exercise
Trial Locations
- Locations (1)
Department of Kinesiology and Applied Physiology, University of Delaware
🇺🇸Newark, Delaware, United States