High Intensity Interval Training (HIT) in Patients With Type 2 Diabetes

Not Applicable

Completed

• Conditions: Type 2 Diabetes
• Interventions: Behavioral: High intensity interval training

• Registration Number: NCT01732705
• Lead Sponsor: University of Copenhagen

Brief Summary

The purpose of this study is to determine the effect of High Intensity Interval Training (HIT) on insulin sensitivity in skeletal muscle in patients with type 2 diabetes.

Detailed Description

Physical exercise increases insulin sensitivity in skeletal muscle in healthy as well as in individuals with type 2 diabetes, but implies a considerable time commitment. High intensity interval training (HIT) is time-efficient exercise consisting of repeated bouts of short duration high intensive workloads. The aim of this study is to determine the effect of HIT in patients with type 2 diabetes, and to clarify the mechanisms of a possible positive effect of HIT.

Exercise is performed as 2 weeks one-legged training on an ergometer bicycle. Thus one leg serves as a control leg. Insulin sensitivity in trained and non-trained muscle will be measured after completion of the overall training program by euglycemic hyperinsulinemic clamp method and a-v catheterization of both legs. Muscle biopsies will be obtained during training period for measuring of muscle glycogen content, and muscle biopsies for further analysis obtained during the experimental day.

Study Timeline

• Study Start: 2012-09
• Study First Submitted: 2012-10-12
• Study First Submitted QC: 2012-11-23
• Study First Posted: 2012-11-26
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Status Verified: 2021-02
• Last Update Submitted: 2021-02-08
• Last Update Posted: 2021-02-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• 10 subjects with Type 2 diabetes. 10 healthy control subjects.
• BMI 28-35
• diet or tablet treatment for diabetes

Exclusion Criteria

• regular physical activity
• diseases other than type 2 diabetes
• insulin treatment

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
HIT (trained leg), Control subject	High intensity interval training	High intensity interval training for one leg (trained leg) (randomized) in control subject
HIT (trained leg) DM	High intensity interval training	High intensity interval training for one leg (trained leg) (randomized) in patient with type 2 diabetes

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity	2 days after last training session (day 17)	Insulin sensitivity in trained and non-trained muscle will be measured by euglycemic hyperinsulinemic clamp method and a-v catheterization of both legs.

Trial Locations

Locations (1)

Xlab, Department of Biomedical Sciences, University of Copenhagen; 🇩🇰 Copenhagen, Denmark