A comparison of the change in stretchability of lung and post-operative collapse of lung detected by lung USG among adults after cardiac surgery undergoing alveolar recruitment maneuvers in ICU with existing standard of care - a randomized controlled trial

Phase 2

Conditions: Health Condition 1: I20-I25- Ischemic heart diseasesHealth Condition 2: I20-I25- Ischemic heart diseases

Registration Number: CTRI/2023/07/055560

Lead Sponsor: Department of Anaesthesiology and Critical Care

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

1. patients consenting/willing to participate in the study

2. ASA I, II ,III

3. Elective cardiac surgery using cardiopulmonary bypass

Exclusion Criteria

1. Not consenting to participate in the study

2. pregnancy

3. on hormonal therapy

4. previous procedures like heart transplant, Pulmonary thrombectomy, aortic arch and other deep dynamic hypoyhermic circulatory arrest surgeriesand concomittent other non cardiac interventions

5. severe pulmonary diseases requiring preoperative inhaled and oral therapies ( interstitial lung disease, chronic bronchitis, airway obstruction, tumor, inflammatory disorders and other lung pathologies

6. patients undergoing deep hypothermic circulatory arrest during surgery

7. emergency surgery

8. EURO score II > 80 %

9. BMI >34.9 Kg/m2

10. diaphragmatic and respiratory muscle dysfunction(amyotrophy,neurological or neuro muscular)

11.chest wall deformity

12.cardiac arrythmias

13.cardiac surgery combined with pulmonary resection

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. change in lung compliance (dynamic & static) <br/ ><br>2. change in atelectasis lung ultrasound scoreTimepoint: - Both parameters at Baseline <br/ ><br>- lung compliance (dynamic & static) every 15 min for two hours after alveolar recruitment maneuver <br/ ><br>- Lung ultrasound score at end of 2 hours after alveolar recruitment maneuver

Secondary Outcome Measures

Name	Time	Method
tidal volume <br/ ><br>ETCO2 <br/ ><br>PEEP <br/ ><br>SPO2 <br/ ><br>VIS <br/ ><br>P/F Ratio <br/ ><br>Aa DO2 <br/ ><br>SaO2 <br/ ><br>PaCO2 <br/ ><br>PaO2Timepoint: Every 15 min for first 2hours after alveolar recruitment maneuver