A Randomized Open Label Controlled Clinical Study To Evaluate The Efficacy Of Mrudweeka Arka Aschyotana In The Management Of Shushkakshipaka With Special Reference To Computer Vision Syndrome
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Significant improvement in the signs and symptoms of Shushkakshipaka.
研究概览
简要总结
Shushkakshipaka is one among the Sarvagata Netra Rogas mentioned by Acharya Sushrutaas well as Vagbhata under Sadhya Netra Roga, caused by Vata and Pitta.
The Lakshanas of Shushkakshipaka according to Acharya Vagbhata are Gharsha, Toda, Bheda, Upadeha, Ruksha, Daruna Vartma, Krichronmeela, Krichra Nimeela, Akshi Vilokana, Shushkatwa, Sheeta Iccha, Shoola and Paka and Acharya Sushruta mentioned Lakshanas like Koonita Akshi, Daruna Vartma, Rookshatwa, Avila Darshanam and Krichronmeelanam.
The signs and symptoms of Shushkakshipaka can be considered similar to those of Computer vision syndrome.
Computer Vision Syndrome (CVS) is defined as a complex of eye and vision problems related to the activities which stress the near vision and which are experienced in relation to or during the use of computers. It encompasses a group of visual symptoms which crop up from the extended viewing of the Video Display Terminal (VDT), when the demands of the task exceed the abilities of the viewer.
Prevalence of CVS is found to be 88% in the people who use computers everyday.
Symptoms of CVS includes dry and irritated eyes, eye strain/fatigue, blurred vision, red eyes, burning eyes, excessive watering, double vision, headache, light sensitivity, glare sensitivity, slowness in changing focus and changes in color perception.
The effect of the CVS has resulted in low performance and extreme discomfort to the sufferer.
The symptoms being vague and slow in onset, leads to intolerable severity by the time the sufferer seeks medical advice.
The use of artificial tears or contact lens wetting solutions is said to be the line of treatment. But with these treatments, the patients of CVS get only symptomatic relief for hours and slowly the frequency of the application to be increased.
Aschyotana is a Netrakriyakalpa, which is indicated in the initial stage of eye diseases which relieves Ruk, Toda, Kandu, Gharsha, Ashru, Daha and Raga.It is a method of instilling the medicated drops into the eye, which penetrates into the channels of Netrasandhi, Sira, Ghrana and Mukha of the Urdhwagabhaga and removes the Prakupita Dosha.Dravyas which are having Madhura Rasa, Snigdha Guna and Madhura Vipaka are advised in Shushkakshipaka.
Arka is considered as Gunotthamma according to Arka Prakasha which are Laghupaki, Vyavayi and Vikasi. Hence the active principles of the drug act quickly on the eye.
The contact time and the absorption of drug in the eye are enhanced by instilling drug with high potency and its shelf life of one year makes it a suitable choice of non-preservative topical drug.
The properties of Mrudweeka which is taken as the trial drug has Madhura, Kashaya Rasa, Sheeta-Guru guna, Madhura Vipaka and it is Chakshushya
Hence in the present study, an effort will be made to evaluate efficacy of Mrudweeka Arka Aschyotana in the management of Shushkakshipaka with special reference to Computer vision syndrome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- None
入排标准
- 年龄范围
- 21.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- All
入选标准
- •Subjects within the age group between 21 to 40 years irrespective of gender, caste, religion, and socio-economic status.
- •Subjects having minimum of two symptoms as per diagnostic criteria.
- •Subjects who are employed professionals with screen time of more than two hours per day during the use of VDT (computers) with history of twelve months.
排除标准
- •Subjects with history of any intraocular surgery.
- •Subjects having any ocular trauma.
- •Subjects diagnosed with cases of any systemic and autoimmune disorders.
- •Subjects diagnosed with inflammatory and infective ocular conditions.
- •Subjects diagnosed with conditions like Cataracts, Corneal opacity, Keratoconus and Glaucoma.
- •Subjects with Drug induced dry eyes.
- •Subjects who are pregnant and lactating women.
结局指标
主要结局
Significant improvement in the signs and symptoms of Shushkakshipaka.
时间窗: Pre-assessment - 0th day | 1st assessment – 7th day | 2nd assessment - 23rd day | Post treatment - 30th day | Follow up - 45th day
Significant improvement in the signs and symptoms of Computer vision syndrome.
时间窗: Pre-assessment - 0th day | 1st assessment – 7th day | 2nd assessment - 23rd day | Post treatment - 30th day | Follow up - 45th day
次要结局
- Generation of in-depth analyzed data on the different aspects of the disease.(Generation of data on possible adverse drug reactions.)
研究者
Dr Kshama Jain
Sri Sri College Of Ayurvedic Science And Research, Bengaluru