Evaluation of Prognostic Monitoring for Breast Cancer Patients With Recurrence and Metastasis After Surgery Via Analysis of Immunoinflammation-related Protein Complexes in Blood
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- blood markers
Overview
Brief Summary
The relationship between immune inflammation-related protein complexes in blood and recurrence or metastasis of breast cancer with completed standard treatment will be studied.
Detailed Description
200 patients with breast cancer and recurrence or metastasis after surgery will be followed up. Peripheral venous blood was collected every 3 to 6 months. Change regularity of breast cancer-specific immune inflammation-related protein complexes in blood at different follow-up time points will be studied. The relationship between disease-specific protein complexes and pathological state of patients will be analyzed.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 36 Years to 60 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •invasive breast cancer patients confirmed by postoperative pathology after surgery for breast lump
- •Breast cancer-related chemotherapy and radiotherapy completed
- •breast cancer patients with recurrence and metastasis after surgery
Exclusion Criteria
- •Aged above 60
- •Breast Carcinoma in situ
- •Women in pregnancy or breastfeeding
- •Suffering from other malignant tumors
- •Non-compliant patient
Outcomes
Primary Outcomes
blood markers
Time Frame: 2 years
The expression of CA153, CEA, CA125 in the blood of the patients, which are measured by electro-chemiluminescence immunoassay.
immune inflammation-related protein complexes
Time Frame: 2 years
The change of immune inflammation-related protein complexes which is measured by gel permeation chromatography.
Secondary Outcomes
No secondary outcomes reported
Investigators
Chang Chen
Principal Investigator
Peking Union Medical College Hospital