Sensorimotor- and whole-body vibration training have the potential to reduce motor- and sensory symptoms of Chemotherapy-induced peripheral neuropathy – a randomized controlled trial
- Conditions
- Chemotherapy-induced peripheral neuropathy (CIPN)
- Registration Number
- DRKS00013027
- Lead Sponsor
- Deutsche Sporthochschule Köln, Universität Basel
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 40
= 18 years old,
oncological disease,
Chemotherapy-induced peripheral neuropathy = grade 1,
healthy controls have to have the same age (+/- 1 year) and gender
- neuropathy of other derivation (Diabetes, HIV etc)
- All Illnesses that prevent physical activity
- Contraindications for whole body vibration (Osteosynthesis, instable osteolysis, acute thrombosis, acute prolaps, implants in lower body, pregnancy, acute wounds, fracture of lower extremity in past 2 years etc
- planed operation
- no signed consent or willingness to allow anonymous data collection
- language restrictions or psychological impairments that prevent the understanding of the written consent and/or instructions given
- uncontrolled cerebral fits
- CNS metastatsis
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All assessments were performed by a blinded examiner at baseline (T0) and after 6 weeks (T1). <br>Primary endpoint is a short clinical test battery: <br>(Achilles- and Patella tendon reflexes (assessed with a reflex hammer), peripheral deep sensitivity (tuning fork), proprioception, sense of position and lower leg strength) <br><br>
- Secondary Outcome Measures
Name Time Method Secondary endpoints are also assessed prior to the intervention (baseline T0) and after the intervention (six weeks later T1): <br>Nerve conduction velocity and amplitude of the N. tibialis and N. suralis, balance control (cumulative sway path in cm, assessed on force plate), neuropathic pain (PAIN Detect questionnaire), subjective report of CIPN related symptoms (FACT-gog-ntx questionnaire), Quality of life (EORTC-QLQ-C-30 questionnaire), level of physical activity (FFKA questionnaire)