Progression in brain abnormalities in psychosis: a 12-year follow-up study
- Conditions
- 10039628psychose - delusions
- Registration Number
- NL-OMON31380
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 600
Subjects have to satisfy the following criteria in order to participate in the study:
- Do not have a pacemaker
- Do not have metal materials in the head (except for dental braces)
- Give written informed consent
- Do not have a major medical history;Specific for patients:
- Do have a DSM-IV diagnosis of Schizophrenia, Schizoaffective disorder or Bipolar disorder, or expereince a first psychotic episode
- Do not chronically use medication, other than psychiatric medication
- Unable to give consent;Specific to healthy subjects:
- Do not have a psychiatric history
- Do not have a first-degree family member with a psychiatric illness
- Do not chronically use medication
- Ferrous objects in or around the body (e.g. braces, glasses, pacemaker, metal fragments)
- Drug or alcohol abuse over a period of six months prior to the experiment
- History of closed-head injury
- History of neurological illness or endocrinological dysfunction
- Claustrophobia
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>What are the age-related trajectories of brain change in patients with<br /><br>schizophrenia, schizoaffective disorder, or bipolar disorder, relative to<br /><br>healthy individuals?</p><br>
- Secondary Outcome Measures
Name Time Method <p>Are the age-related brain changes seen in patients clinically relevant, i.e.<br /><br>the association with medication intake, outcome and symptoms will be tested.<br /><br>Can the age-related brain changes be explained by genetic or environmental<br /><br>factors?</p><br>