Psychotic disorder: positive, negative and cognitive symptoms in daily life
- Conditions
- psychosisschizophrenia10039628
- Registration Number
- NL-OMON41303
- Lead Sponsor
- niversiteit Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion criteria for the early psychosis group are: (i) the presence of attenuated psychotic symptoms, brief limited intermittent psychotic symptoms, genetic risk or the occurrence of a psychotic episode according to DSM-IV criteria, , (ii) age 15-35 years, (iii) sufficient knowledge of the Dutch language.;Inclusion criteria for the chronic psychosis group are: (i) life time occurrence of a psychotic episode according to DSM-IV criteria, (ii) illness onset > 6 years, (iii) age 25-55 years, (iv) sufficient knowledge of the Dutch language.
Exclusion criteria for the early psychosis group are: (i) onset of symptoms >2 years, (ii) frequent drug use (>2 times a week), (iii) Mental Retardation (IQ score <70), (iiii) psychosis with organic cause. ;Exclusion criteria for the chronic psychosis group are: (i) illness onset <6 years, (ii) frequent drug use (>2 times a week), (iii) Mental Retardation (IQ score <70), (iiii) psychosis with organic cause.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Cognition assessed in daily life<br /><br>Social cognition assessed in daily life<br /><br>Negative symptoms assessed in daily life<br /><br>Positive symptoms assessed in daily life<br /><br>Fluctuations in both cognition and social cognition in daily life and<br /><br>the influence of these fluctuations on positive and negative symptoms</p><br>
- Secondary Outcome Measures
Name Time Method <p>Saliva samples will be collected for the purpose of molecular genetic studies.<br /><br>These studies aim at selecting SNPs (parts of the DNA where one nucleotide is<br /><br>different from one person to another) that contribute to the psychosis<br /><br>phenotype. </p><br>